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March 22, 2025Journal of Clinical MedicineOpen Access

Median SV increased significantly from 40.02 mL at baseline to 69.83 mL at 3 months (p < 0.0001), and median TPRI decreased significantly from 2537 dn s/cm5 m2 to 1307 dn s/cm5 m2 (p < 0.0001).

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Why the study?

Non-invasive methods to assess the acute hemodynamic effects of cardiac contractility modulation are critical to optimize care and guide treatment in heart failure patients ineligible for CRT.

Does cardiac contractility modulation improve stroke volume and total peripheral resistance index in heart failure patients?

Comparison

Hemodynamic parameters at 1 week, 1 month, and 3 months post-implantation vs baseline

Design

Pilot study

Follow-up

3 months

Authors

AMAndrea MadeoSBSilvana De BonisACAnna Lucia Cavaliere

Discussion

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Overview

NICaS may enable non-invasive SV monitoring during CCM; leaves open need for larger randomized validation before practice change.

Structured PICO

Does cardiac contractility modulation improve stroke volume and total peripheral resistance index in heart failure patients?

P
Population
8 heart failure patients, median age 64.6 years, median LVEF 34.5%
I
Intervention
Implantation of the Optimizer Smart Mini cardiac contractility modulation (CCM) device
O
Outcome
Stroke volume (SV) and total peripheral resistance index (TPRI) measured using the non-invasive bioimpedance-based system (NICaS) at 1 week, 1 month, and 3 months post-implantationsurrogate

Cardiac contractility modulation significantly improved stroke volume and reduced total peripheral resistance index in heart failure patients at 3 months, as measured non-invasively by bioimpedance.

Cite This Study

Madeo et al. (2025) studied this question.

synapsesocial.com/papers/6a7c271d073f483584dfbb77https://doi.org/10.3390/jcm14072172
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1NON–INVASIVE ASSESSMENT OF CARDIAC HEMODYNAMICS BY BIO–IMPEDANCE IN A PATIENT WITH HEART FAILURE AND EXCELLENT RESPONSE TO CARDIAC RESYNCHRONIZATION THERAPY2024
  2. 2Dynamics of heart failure markers and cardiac reverse remodeling in patients receiving cardiac contractility modulation therapy2021 · 4 citations
  3. 3QUALITY OF LIFE IMPROVEMENT AND REDUCTION IN HOSPITALIZATIONS IN PATIENTS WITH HEART FAILURE UNDERGOING CARDIAC CONTRACTILITY MODULATION (CCM) THERAPY: A SINGLE–CENTER EXPERIENCE2026
  4. 4HF Etiology and cardiac contractility modulation therapy2024
  5. 5Effects of Cardiac Contractility Modulation Therapy on Right Ventricular Function: An Echocardiographic Study2022 · 13 citations