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March 1, 1996Journal of Cardiovascular Pharmacology

Effect of Gender and Sex Steroids on the Contractile Response of Canine Coronary and Renal Blood Vessels

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Population

Isolated preparations of the left anterior descending coronary artery, left circumflex coronary artery, and…

Comparison

Sex steroids and antiandrogen/antiestrogen… vs Untreated controls or opposite sex

Design

Preclinical

Authors

JKJohn W. KaranianNational Institutes of Health Clinical CenterPRPeter W. RamwellGeorgetown University

Discussion

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Implication

Animal data indicate sex hormone modulation of TXA2 responses; leaves open translation to human coronary and renal vasoreactivity.

Structured PICO

P
Population
Isolated preparations of the left anterior descending coronary artery (LAD), left circumflex coronary artery, and renal artery and vein of sexually mature dogs
I
Intervention
Sex steroids (testosterone, estrogen) and antiandrogen/antiestrogen treatments (flutamide, cyproterone acetate, tamoxifen)
C
Comparator
Untreated controls or opposite sex
O
Outcome
Isotonic contractile response (maximum response and EC50) to the thromboxane A2 (TXA2)-mimetic U46619 and norepinephrinesurrogate

Smooth muscle reactivity of dog coronary arteries to TXA2 and catecholamines exhibits sex differences and is regulated by both androgens and estrogens.

Cite This Study

Karanian et al. (1996) studied this question.

synapsesocial.com/papers/6a7cc1fe80d29ce2cbfaba06https://doi.org/10.1097/00005344-199603000-00002
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