Why the study?
Does intracoronary endothelin induce myocardial ischaemia and coronary vasoconstriction in intact rabbits?
Population
Adult male Japanese white rabbits (n=29) weighing 2.7-3.5 kg
Design
Preclinical
Authors
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Endothelin may mediate microvascular ischemia in intact hearts; leaves open translation to human coronary syndromes.
Does intracoronary endothelin induce myocardial ischaemia and coronary vasoconstriction in intact rabbits?
Endothelin induces myocardial ischemia in intact rabbits through diffuse constriction of small coronary arteries rather than large epicardial vessel spasm or platelet thrombi.
Hirata et al. (1990) studied this question.
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