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July 23, 2020ESC Heart FailureOpen Access

A Comprehensive Individual Patient Data Meta-Analysis of the Effects of Cardiac Contractility Modulation on Functional Capacity and Heart Failure-Related Quality of Life

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Why the study?

Cardiac contractility modulation has emerged as a promising device treatment for HF in patients not indicated for cardiac resynchronization therapy, warranting a comprehensive individual patient data meta-analysis of functional capacity and quality of life.

Does cardiac contractility modulation improve functional capacity and quality of life in heart failure patients not indicated for cardiac resynchronization therapy?

Population

Patients with HF not indicated for CRT across 5 trials

Comparison

CCM vs control

Design

Individual patient data meta-analysis of prospective randomized controlled trials and one single-arm trial

Authors

FGFrancesco GiallauriaGCGianluigi CuomoAPAlessandro Parlato

Discussion

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Overview

May warrant consideration in CRT-ineligible HFrEF; leaves open effects on hospitalization and survival.

Structured PICO

Does cardiac contractility modulation improve functional capacity and quality of life in heart failure patients not indicated for cardiac resynchronization therapy?

P
Population
861 heart failure patients not indicated for cardiac resynchronization therapy (pooled from 4 RCTs enrolling 801 participants and 1 single-arm non-randomized trial enrolling 60 participants)
I
Intervention
Cardiac contractility modulation (CCM)
C
Comparator
Control
O
Outcome
Peak oxygen consumption (peak VO2), 6 min walk test distance, and quality of life measured by Minnesota Living with Heart Failure Questionnaire (MLWHFQ)surrogate

Cardiac contractility modulation provides statistically significant and clinically meaningful benefits in functional capacity and heart failure-related quality of life in patients not indicated for cardiac resynchronization therapy.

Cite This Study

Giallauria et al. (2020) studied this question.

synapsesocial.com/papers/6a810e651325e503433c78bbhttps://doi.org/10.1002/ehf2.12902
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Impact of Exercise Rehabilitation on Exercise Capacity and Quality-of-Life in Heart Failure2019 · 296 citations
  2. 2Clinical effects of long-term cardiac contractility modulation (CCM) in subjects with heart failure caused by left ventricular systolic dysfunction2017 · 44 citations
  3. 3Cardiac Contractility Modulation: Mechanisms of Action in Heart Failure with Reduced Ejection Fraction and Beyond2018 · 119 citations
  4. 4Safety, Performance, and Efficacy of Cardiac Contractility Modulation Delivered by the 2-Lead Optimizer Smart System2020 · 75 citations
  5. 5Cardiac Contractility Modulation: A Technical Guide for Device Implantation2017 · 21 citations