Why the study?
Does the dose of captopril correlate with arterial blood pressure and plasma renin, aldosterone, and potassium levels in severely hypertensive patients?
Population
12 severely hypertensive patients whose blood pressure had been previously controlled by captopril, either…
Comparison
Captopril 32.5, 75, and 150 mg/day in three… vs Other doses of captopril.
Design
RCT, random sequence, double-blind
Authors
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Supports captopril dose titration in severe hypertension; confirms dose-dependent effects on BP and RAAS biomarkers in an RCT.
Does the dose of captopril correlate with arterial blood pressure and plasma renin, aldosterone, and potassium levels in severely hypertensive patients?
Captopril demonstrates a dose-dependent effect on blood pressure and renin-angiotensin-aldosterone system parameters in severely hypertensive patients.
Aldigier et al. (1981) studied this question.
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