April 1, 1994The Journal of Clinical Endocrinology & Metabolism

Fasting affects serum insulin-like growth factors (IGFs) and IGF-binding proteins differently in patients with noninsulin-dependent diabetes mellitus versus healthy nonobese and obese subjects.

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Why the study?

Does fasting affect serum IGFs and IGFBPs differently in patients with NIDDM compared to healthy obese and nonobese subjects?

Population

Obese patients with noninsulin-dependent diabetes mellitus, healthy obese subjects, and healthy nonobese…

Comparison

4 days of fasting vs Healthy obese and nonobese subjects undergoing…

Design

Cohort

Follow-up

4 days

Authors

PBPeter BangLinköping University KBKerstin BrismarKarolinska University Hospital RRR G RosenfeldKarolinska Institutet

Discussion

Member takes

Implication

Blunted IGF-I response to fasting in NIDDM warrants no practice change; leaves open GH-insulin interactions for prospective study.

Structured PICO

Does fasting affect serum IGFs and IGFBPs differently in patients with NIDDM compared to healthy obese and nonobese subjects?

Population

Obese patients with noninsulin-dependent diabetes mellitus (NIDDM), healthy obese (OB) subjects, and healthy nonobese (NOB) subjects.

Intervention

4 days of fasting

Comparator

Healthy obese and nonobese subjects undergoing the same fasting protocol

Outcome

Response of serum IGF-I concentrations to fastingsurrogate

Fasting-induced decreases in serum IGF-I are blunted in NIDDM patients, likely due to differences in GH status and insulin resistance.

Cite This Study

Bang et al. (1994) studied this question.

synapsesocial.com/papers/6a82d8be9aaf5d32a4b28e82 https://doi.org/10.1210/jcem.78.4.7512573

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Fasting affects serum insulin-like growth factors (IGFs) and IGF-binding proteins differently in patients with noninsulin-dependent diabetes mellitus versus healthy nonobese and obese subjects.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Fasting affects serum insulin-like growth factors (IGFs) and IGF-binding proteins differently in patients with noninsulin-dependent diabetes mellitus versus healthy nonobese and obese subjects.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider