Why the study?
Does the combination of vasodilators and beta-blockers improve antihypertensive efficacy and tolerability?
Does the combination of vasodilators and beta-blockers improve antihypertensive efficacy and tolerability?
Vasodilators are best utilized as antihypertensive agents when added to beta-blockers, which mitigate reflex cardiac stimulation and provide a synergistic effect.
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Supports combining beta-blockers with vasodilators to blunt reflex effects; leaves open applicability to modern regimens.
R. Zacest (1976) studied this question.
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