June 1, 2002The Journal of PhysiologyOpen Access

Chronotropic effects of nitric oxide in the denervated human heart

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Why the study?

Does nitric oxide exert a direct chronotropic effect on the denervated human heart?

Population

9 human cardiac transplant recipients with a denervated donor heart

Comparison

Systemic injection of nitric oxide synthase… vs Injection of the non-NO-dependent…

Authors

SCSaqib ChowdharyWythenshawe Hospital DHDerek HarringtonSt. Norbert College RBRobert S. BonserInterventional / Structural Cardiology

Discussion

Member takes

Implication

NO directly accelerates the denervated human heart; confirms tonic positive chronotropy independent of autonomic reflexes.

Structured PICO

Does nitric oxide exert a direct chronotropic effect on the denervated human heart?

Population

9 human cardiac transplant recipients with a denervated donor heart

Intervention

Systemic injection of nitric oxide synthase inhibitor N(G)-monomethyl-L-arginine (L-NMMA) (3 mg kg(-1)) or increasing bolus doses of the nitric oxide donor, sodium nitroprusside (SNP)

Comparator

Injection of the non-NO-dependent vasoconstrictor, phenylephrine (100 microg)

Outcome

Change in R-R interval duration and mean arterial pressuresurrogate

Nitric oxide exerts a tonic, direct, positive chronotropic influence on the human sino-atrial node, independent of autonomic reflexes.

Cite This Study

Chowdhary et al. (2002) studied this question.

synapsesocial.com/papers/6a868bc19d47a4cf9232fd07 https://doi.org/10.1113/jphysiol.2001.015107

Topics

Heart transplantation

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Chronotropic effects of nitric oxide in the denervated human heart

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Chronotropic effects of nitric oxide in the denervated human heart

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider