April 1, 2001Stroke

G-Protein β3 Subunit and α-Adducin Polymorphisms and Risk of Subclinical and Clinical Stroke

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Why the study?

Do ADD1 G/W460 and GNbeta3 825C/T polymorphisms increase the risk of subclinical and clinical stroke in a middle-aged American population?

Structured PICO

Do ADD1 G/W460 and GNbeta3 825C/T polymorphisms increase the risk of subclinical and clinical stroke in a middle-aged American population?

Population

Middle-aged American population from the Atherosclerosis Risk in Communities (ARIC) Study. Subclinical stroke analysis included 202 cases and 211 controls (MRI-CRS). Clinical ischemic stroke analysis included 231 cases and 984 controls (CRS).

Intervention

Presence of alpha-adducin (ADD1) G/W460 and G-protein beta3 subunit (GNbeta3) 825C/T polymorphisms

Comparator

Absence of the respective alleles

Outcome

Subclinical stroke (determined by cerebral MRI) and incidence of clinical ischemic strokehard clinical

The GNbeta3 825C/T polymorphism is associated with an increased risk of incident clinical ischemic stroke in white, but not black, middle-aged Americans, independent of blood pressure.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Should not yet inform genetic screening for stroke; leaves open confirmation of race-specific associations in prospective cohorts.

Cite This Study

Morrison et al. (2001) studied this question.

synapsesocial.com/papers/6a869b92adfdeade3289c79b https://doi.org/10.1161/01.str.32.4.822

Topics

Hypertension management

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G-Protein β3 Subunit and α-Adducin Polymorphisms and Risk of Subclinical and Clinical Stroke

Structured PICO

Discussion

Implication

Cite This Study

Topics

G-Protein β3 Subunit and α-Adducin Polymorphisms and Risk of Subclinical and Clinical Stroke

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider