Reduced Response to Activated Protein C Is Associated with Increased Risk for Cerebrovascular Disease

115 patients with a history of myocardial infarction; 112 patients with a history of stroke, transient ischemic attack, or both; and 222 age-matched controls without arterial disease from the Rotterdam Study cohort. Patients using anticoagulant drugs were excluded.

Response to activated protein C (APC) and factor V Leiden mutation

Age-matched controls without arterial disease

Prevalence of cerebrovascular disease and myocardial infarctionhard clinical