March 1, 1979Journal of Cardiovascular Pharmacology

Sodium Intake and Plasma Angiotensin Level as Modulators of Adrenal and Uterine Angiotensin II Receptors in the Rat

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Population

Rats (adrenal cortex and myometrium tissues)

Design

Preclinical

Authors

MDMarie‐Aude DevynckCentre National de la Recherche Scientifique MPMarie-Gabrielle PernolletHôpital Necker-Enfants Malades PMP. G. MatthewsAustin Health

Discussion

Member takes

Implication

Rat data suggest sodium and angiotensin II regulate receptors; leaves open human translation and clinical relevance.

Structured PICO

Population

Rats (adrenal cortex and myometrium tissues)

Intervention

Variations in sodium intake (low and high Na+ diets), DOCA hypertension, one-kidney Goldblatt hypertension, and suppression of circulating angiotensin II

Outcome

Number of angiotensin II receptors in adrenal gland and uterus (measured via tritiated angiotensin binding)surrogate

Sodium status and endogenous angiotensin II levels modulate the number of angiotensin II receptors in rat adrenal and uterine tissues.

Cite This Study

Devynck et al. (1979) studied this question.

synapsesocial.com/papers/6a87f1f6c2c4a92245582680 https://doi.org/10.1097/00005344-197903000-00001

Topics

Hypertension management

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Sodium Intake and Plasma Angiotensin Level as Modulators of Adrenal and Uterine Angiotensin II Receptors in the Rat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Sodium Intake and Plasma Angiotensin Level as Modulators of Adrenal and Uterine Angiotensin II Receptors in the Rat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider