Why the study?
Does variation of sodium intake or experimental hypertension alter the number of angiotensin II receptors in rat adrenal gland and myometrium?
Does variation of sodium intake or experimental hypertension alter the number of angiotensin II receptors in rat adrenal gland and myometrium?
Alterations of angiotensin II receptors alone cannot fully explain the variations in target-cell sensitivity to angiotensin II during sodium balance changes.
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Receptor alterations insufficient to explain angiotensin II sensitivity shifts in rats; leaves open additional mechanisms for human sodium-balance studies.
Angiotensin II receptors from rat adrenal gland and myometrium were studied during variation of sodium intake. 2. In both target-tissues low Na+ diet increased the number of receptors whereas a high Na+ diet did not modify the adrenocortical receptors but increased the number of uterine receptors. 3. Deoxycorticosterone and one kidney Goldblatt hypertension were associated with a decrease in the number of adrenal receptors. 4. Alterations of angiotensin II receptors alone cannot explain satisfactorily the variations of sensitivity of target-cells to angiotensin II during sodium balance changes.
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Devynck et al. (1978) studied this question.
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