Why the study?
How does the development of renovascular hypertension alter cardiac sympathetic and vagal tone in rats?
Population
Conscious rats with two-kidney, one-clip (2K1C) and one-kidney, one-clip (1K1C) renal hypertension
Design
Preclinical
Authors
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Animal data on autonomic imbalance in renovascular hypertension should not change practice; leaves open human mechanistic relevance.
How does the development of renovascular hypertension alter cardiac sympathetic and vagal tone in rats?
In rat models of renovascular hypertension, tachycardia is maintained by an increase in cardiac sympathetic tone and a decrease in vagal tone, with the 1K1C model showing more persistent alterations than the 2K1C model.
Cabrai et al. (1991) studied this question.
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