Prevention of perioperative deep vein thrombosis in general surgery: A multicentre double blind study comparing two doses of Logiparin and standard heparin

1290 patients undergoing general surgery with at least one recognized risk factor for DVT (malignancy, age over 60 years, or a history of varicose veins) and no contraindication to heparin therapy.

Logiparin (low molecular weight heparin) 2500 units daily or 3500 units daily, administered subcutaneously 2 hours before surgery and continued for 7-10 days.

Unfractionated heparin 5000 units twice daily, administered subcutaneously 2 hours before surgery and continued for 7-10 days.

Deep vein thrombosis detected by daily 125I-labelled fibrinogen uptake tests (FUTs) from day 2 to day 7 and confirmed by phleboangiography.hard clinical