Key result
Confirmed prehypertensives had a higher baseline common carotid artery intima-media thickness than normotensives (adjusted difference +93 microm), but short-term progression was not accelerated.
Why the study?
Is carotid intima-media thickness increased in normotensive subjects who progress to hypertension compared to those who remain normotensive?
Population
1536 subjects from the population-based Mexico City Diabetes Study, including 136 confirmed prehypertensives.
Comparison
Progression to hypertension vs Normotensive subjects and hypertensive subjects
Design
Cohort
Follow-up
3.5 years
Authors
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May not alter short-term prehypertension management; leaves open long-term prognostic value of baseline IMT differences.
Cohort (n=1,536)
Is carotid intima-media thickness increased in normotensive subjects who progress to hypertension compared to those who remain normotensive?
Mean Difference: 93
Absolute Event Rate: 720% vs 615%
Prehypertension is associated with increased carotid intima-media thickness independently of blood pressure levels, suggesting early vascular changes occur before clinical hypertension develops.
Femia et al. (2007) conducted a cohort in Prehypertension (n=1,536). Progression to hypertension (confirmed prehypertensives) vs. Normotensives was evaluated on Baseline common carotid artery far-wall intima-media thickness (MD 93). Confirmed prehypertensives had a higher baseline common carotid artery intima-media thickness than normotensives (adjusted difference +93 microm), but short-term progression was not accelerated.
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