January 1, 1986Journal of Perinatal MedicineOpen Access

The concentration of bupivacaine in fetal organs during obstetrical epidural analgesia

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Population

n=2 non-viable human fetuses

Design

Case_series

Authors

WMW. Müller-HolveAsklepios Klinik Barmbek LMLudwig von MeyerLudwig-Maximilians-Universität München PNPeter C. NaglerGoddard Space Flight Center

Discussion

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Implication

May warrant caution to avoid fetal acidosis with epidural bupivacaine; single case leaves open fetal distribution risks.

Structured PICO

Population

n=2 non-viable human fetuses (one terminated at 24 weeks of pregnancy who died 3 minutes after birth; one born at 40 weeks with anencephaly who lived 20 minutes)

Intervention

Obstetrical epidural analgesia with bupivacaine in customary doses

Outcome

Concentration of bupivacaine in fetal organssurrogate

Bupivacaine accumulates in the fetal liver and lungs, highlighting the importance of avoiding fetal acidosis during epidural analgesia to prevent accelerated transfer of the anesthetic and potential fetal distress.

Cite This Study

Müller-Holve et al. (1986) studied this question.

synapsesocial.com/papers/6a8996d144eed047faeb1b16 https://doi.org/10.1515/jpme.1986.14.4.219

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The concentration of bupivacaine in fetal organs during obstetrical epidural analgesia

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The concentration of bupivacaine in fetal organs during obstetrical epidural analgesia

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider