Key result
Exercise training in rats maintained T-tubule density during physiologic and mild pathologic hypertrophy, and increased T-tubule density by 40% (P<0.05) after severe pathologic remodeling.
Why the study?
Does exercise training improve T-tubule density and spacing in normal and remodeled rat hearts?
Population
Rat models including normal rats, a model of metabolic syndrome with pressure overload-induced concentric…
Comparison
Exercise training vs Sedentary controls
Design
Preclinical
Authors
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Exercise training may mitigate T-tubule loss in severe remodeling; leaves open translation to human HF.
Does exercise training improve T-tubule density and spacing in normal and remodeled rat hearts?
Exercise training partially corrects T-tubule density loss in severe pathologic remodeling (post-MI heart failure) and maintains relative density during physiologic and mild concentric pathologic hypertrophy in rat models.
Kemi et al. (2010) studied Normal, metabolic syndrome with pressure overload-induced concentric LVH, and post-MI heart failure. Exercise training vs. Sedentary/control rats was evaluated on Density and spacing of left ventricle cardiomyocyte T-tubules and cardiomyocyte volume. Exercise training in rats maintained T-tubule density during physiologic and mild pathologic hypertrophy, and increased T-tubule density by 40% (P<0.05) after severe pathologic remodeling.
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