Key result
L-arginine and its derivative RVC-578 administered during retinal ischemia significantly improved electroretinogram b-wave amplitude recovery to 64% and 51% of original height vs 20% in controls.
Why the study?
Does L-arginine or its derivatives improve retinal function recovery in a rat model of retinal ischemia?
Population
Rat model of retinal ischemia induced by 30-minute occlusion of the central retinal artery
Comparison
L-arginine or N alpha-benzoyl-L-arginine ethyl… vs Corresponding controls
Design
Preclinical
Follow-up
240 minutes
Authors
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May support preclinical development of L-arginine derivatives for retinal ischemia; leaves open any human translation.
Does L-arginine or its derivatives improve retinal function recovery in a rat model of retinal ischemia?
Absolute Event Rate: 64% vs 20%
L-arginine and its lipophilic derivatives significantly improve the recovery of retinal function after ischemia in a rat model, likely via increased NO production.
LIU et al. (1995) studied Retinal ischemia. L-arginine (RVC-579) and N alpha-benzoyl-L-arginine ethyl ester (RVC-578) vs. Control was evaluated on Recovery of b-wave amplitude of electroretinogram. L-arginine and its derivative RVC-578 administered during retinal ischemia significantly improved electroretinogram b-wave amplitude recovery to 64% and 51% of original height vs 20% in controls.
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