Why the study?
Does saralasin infusion or dietary sodium alteration reveal volume- or renin-dependent mechanisms for hypertension in chronic haemodialysis patients?
Population
59 non-nephrectomized haemodialysis patients, of whom 42 were hypertensive.
Comparison
Saralasin infusion; a subset of 13 patients was… vs Pre-infusion baseline; high versus low dietary…
Design
Cohort
Authors
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Questions volume- or renin-dependent hypertension models in hemodialysis; leaves open multifactorial mechanisms for prospective study.
Does saralasin infusion or dietary sodium alteration reveal volume- or renin-dependent mechanisms for hypertension in chronic haemodialysis patients?
Hypertension in haemodialysis patients cannot be adequately explained by simple abnormalities in volume homeostasis or the renin-angiotensin system.
McGrath et al. (1978) studied this question.
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