Key result
Adenosine receptor agonists caused vasodilation in isolated equine digital veins, supporting the presence of A2A-adenosine receptors on vascular smooth muscle cells.
Population
Isolated equine digital veins (EDVs) denuded of endothelium
Comparison
Adenosine receptor agonists and antagonists vs Equine digital arteries
Design
Preclinical
Authors
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May inform equine vascular research; leaves open in vivo translation or clinical relevance in horses.
Adenosine acts as a potent vasodilator in equine digital veins primarily via A2A-adenosine receptors located on vascular smooth muscle cells, suggesting a role in regulating local blood flow.
Elliott et al. (1998) studied this question. Adenosine receptor agonists was evaluated on Vasodilator potency. Adenosine receptor agonists caused vasodilation in isolated equine digital veins, supporting the presence of A2A-adenosine receptors on vascular smooth muscle cells.
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