Key result
Nitrous oxide (70%) during laparoscopic cholecystectomy caused no significant differences in operating conditions or bowel distension, with surgeons correctly guessing its use only 44% of the time.
Why the study?
Does nitrous oxide worsen operating conditions or bowel distension in healthy patients undergoing laparoscopic cholecystectomy?
Population
50 healthy patients undergoing laparoscopic cholecystectomy
Comparison
Isoflurane with 70% nitrous oxide in oxygen for… vs Isoflurane in an air/O2 mixture for maintenance…
Design
RCT, Randomly assigned, Double-blind protocol design
Follow-up
Intraoperative and immediate postoperative
Authors
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Supports nitrous oxide use without compromising conditions in laparoscopic cholecystectomy; challenges traditional avoidance and extends RCT safety data.
RCT (n=50)
Double-blind
Does nitrous oxide worsen operating conditions or bowel distension in healthy patients undergoing laparoscopic cholecystectomy?
Nitrous oxide does not have clinically apparent deleterious effects on operating conditions or bowel distension during laparoscopic cholecystectomy.
Taylor et al. (1992) conducted an RCT in Laparoscopic cholecystectomy (n=50). Nitrous oxide (N2O) vs. Air/O2 mixture was evaluated on Operating conditions and bowel distension. Nitrous oxide (70%) during laparoscopic cholecystectomy caused no significant differences in operating conditions or bowel distension, with surgeons correctly guessing its use only 44% of the time.
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