What is the clinical evidence from this study?

Study design: Other. Population: Healthy ponies. Intervention: Aspirin. Primary outcome: Template bleeding time.

What does this research mean for the field?

Aspirin significantly prolongs bleeding time in healthy ponies up to 48 hours at approximately 11-12 mg/kg and up to 4 hours at 4 mg/kg via prolonged inhibition of platelet cyclo-oxygenase. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

March 1, 1991Equine Veterinary Journal

Antithrombotic actions of aspirin in the horse

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Key result

High-dose aspirin prolongs bleeding time for ~48 hours in healthy ponies.

Why the study?

Does aspirin prolong bleeding time and inhibit platelet aggregation in normal, healthy ponies?

Population

Normal, healthy ponies

Design

Preclinical

Follow-up

48 hours

Authors

HCH. CambridgeRoyal Veterinary College PLP. LeesUniversity of London RHR.E. HookeUniversity of London

Discussion

Member takes

Implication

May inform equine antithrombotic dosing; leaves open clinical translation and efficacy in diseased horses.

Structured PICO

Does aspirin prolong bleeding time and inhibit platelet aggregation in normal, healthy ponies?

Population

Normal, healthy ponies evaluated for the antithrombotic effects of aspirin.

Intervention

Aspirin at 4 mg/kg and 11-12 mg/kg bodyweight

Outcome

Template bleeding timesurrogate

Aspirin exhibits irreversible inhibition of platelet cyclo-oxygenase in horses, prolonging bleeding time and suggesting potential utility in equine antithrombotic therapy.

Limitations

The relationship between skin bleeding time in normal horses and improvement of clinical conditions requires further research and evaluation in clinical trials.
TXB2 measurement appears to overestimate the duration of antithrombotic effects of aspirin in vivo.
The relationship between skin bleeding time in normal horses and improvement of clinical conditions requires further research and evaluation in clinical trials
TXB2 measurement appears to overestimate the duration of antithrombotic effects of aspirin in vivo

Cite This Study

Cambridge et al. (1991) studied Healthy ponies. Aspirin was evaluated on Template bleeding time. Aspirin significantly prolonged bleeding time up to 48 hours at 12 mg/kg and up to 4 hours at 4 mg/kg in healthy ponies.

synapsesocial.com/papers/6aa522143f249affa9f4bdff https://doi.org/10.1111/j.2042-3306.1991.tb02736.x

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Antithrombotic actions of aspirin in the horse

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Antithrombotic actions of aspirin in the horse

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider