Key result
Hypothermia decreases in vitro hepatic metabolism of propranolol and verapamil vs normothermia.
Why the study?
Previous in vivo studies showed that hypothermia alters propranolol pharmacokinetics by reducing drug clearance, but the effect on hepatic metabolism of propranolol and verapamil was unclear.
Does hypothermia reduce the hepatic metabolic elimination of propranolol and verapamil in rat hepatic microsomes?
Population
Rat hepatic microsome preparations
Comparison
Hypothermia (26 degrees C) vs normothermia (37 degrees C)
Design
In vitro metabolic study
Authors
Loading...
May inform propranolol/verapamil dosing during hypothermic bypass; in vitro findings leave clinical relevance open pending in vivo confirmation.
Does hypothermia reduce the hepatic metabolic elimination of propranolol and verapamil in rat hepatic microsomes?
p-value: p=<0.001
Hypothermia significantly decreases the hepatic metabolic elimination of propranolol and verapamil in vitro, suggesting potential pharmacokinetic alterations during hypothermic cardiopulmonary bypass.
McAllister et al. (2008) studied Drug metabolism during hypothermia. Hypothermia (26 degrees C) vs. Normothermia (37 degrees C) was evaluated on Amount of drug substrate remaining (metabolism of propranolol and verapamil) (p=<0.001). Hypothermia significantly decreased the in vitro hepatic metabolic elimination of both propranolol and verapamil compared to normothermia (p<0.001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: