Key result
In patients with unexplained dyspnoea and preserved ejection fraction, an abnormal increase in pulmonary capillary wedge pressure during exercise independently predicted all-cause mortality (HR 1.16; P=0.03).
Why the study?
Does exercise-induced pulmonary capillary wedge pressure elevation predict long-term mortality in patients with unexplained dyspnoea and preserved ejection fraction?
Does exercise-induced pulmonary capillary wedge pressure elevation predict long-term mortality in patients with unexplained dyspnoea and preserved ejection fraction?
Hazard Ratio: 1.16
p-value: p=0.03
No takes yet. Share an insight, caveat, or question.
Early HFpEF, characterized by exercise-induced PCWP elevation despite normal resting pressures, is a distinct pathological entity associated with increased long-term mortality.
Barry A. Borlaug (2014) conducted an editorial in Unexplained dyspnoea and EF >50% (n=355). Exercise pulmonary capillary wedge pressure (PCWL) vs. Normal exercise PCWP was evaluated on All-cause mortality (HR 1.16, p=0.03). In patients with unexplained dyspnoea and preserved ejection fraction, an abnormal increase in pulmonary capillary wedge pressure during exercise independently predicted all-cause mortality (HR 1.16; P=0.03).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: