Key result
A 2-hour hyperinsulinemic clamp fails to reach steady state, underestimating insulin sensitivity vs a 3-hour clamp.
Why the study?
It was uncertain whether steady state is reached within 2 hours of insulin infusion during isoglycemic hyperinsulinemic clamp in elderly hypertensive patients with LVH compared to healthy subjects.
Does a 2-hour isoglycemic hyperinsulinemic clamp reach steady state for measuring insulin sensitivity in elderly patients with hypertension and left ventricular hypertrophy?
Population
26 young healthy subjects and 43 elderly patients with unmedicated essential hypertension and LVH
Comparison
2-hour M/IG vs 3-hour Sip; young healthy subjects vs elderly hypertensive patients
Design
Observational study with oral glucose tolerance test and isoglycemic hyperinsulinemic clamp
Authors
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Supports shorter 2-h clamps for M/IG; leaves open validation of steady-state assumptions in hypertension.
Observational (n=69)
Does a 2-hour isoglycemic hyperinsulinemic clamp reach steady state for measuring insulin sensitivity in elderly patients with hypertension and left ventricular hypertrophy?
Absolute Event Rate: 12.21% vs 10%
p-value: p=<0.001
A 2-hour isoglycemic hyperinsulinemic clamp underestimates insulin sensitivity in elderly hypertensive patients because steady state is not reached, highlighting a higher prevalence of insulin resistance in this population.
Michael Hecht Olsen (1999) conducted an observational in Essential hypertension and left ventricular hypertrophy (n=69). Isoglycemic hyperinsulinemic clamp vs. Healthy subjects was evaluated on Glucose uptake index (M/IG) at 2 hours versus 3 hours in hypertensive patients (p=<0.001). In elderly hypertensive patients, a 2-hour isoglycemic hyperinsulinemic clamp fails to reach steady state, underestimating insulin sensitivity compared to a 3-hour clamp (M/IG 10.0 vs 12.21; P<0.001).
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