Key result
Guanabenz is linked to reversible ~15% reductions in GFR and renal blood flow.
Why the study?
The effects of guanabenz acetate therapy on renal function, renal hemodynamics, and body fluid composition in hypertensive patients were not fully characterized.
Observational (n=17)
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May warrant renal monitoring with guanabenz; leaves open long-term renal outcome effects in hypertension.
John H. Bauer (1983) conducted an observational in Hypertension (n=17). Guanabenz therapy vs. Withdrawal was evaluated on Renal function, renal hemodynamics, and body fluid composition. Guanabenz therapy caused a modest but reversible reduction in glomerular filtration rate (12% to 18%), effective renal plasma flow (9% to 17%), and renal blood flow (12% to 20%).
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