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September 4, 2025Open Access

Supplementary Legends from Mitochondrial HSP90 Paralog TRAP1 Deletion Drives Glutamine Addiction in Tumor Cells via Destablization of the Cys/Glu Antiporter SLC7A11/xCT

Abhinav Joshi Li Dai Marisa Maisiak Sunmin Lee Elizabeth Lopez Takeshi Itoh Len Neckers

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Key Points

TRAP1 deletion leads to glutamine addiction in tumor cells, highlighting the role of mitochondrial proteins.
Destabilization of SLC7A11/xCT is a critical mechanism driving this addiction in cancer cells.
The study provides supplementary legends that outline various figures and tables related to the findings.
Targeting mitochondrial remodeling may offer new strategies for disrupting tumor metabolism.

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Implication

Supplementary legends reveal mechanisms of glutamine addiction through SLC7A11/xCT destabilization in tumor cells.

Abstract

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Cite This Study

Joshi et al. (2025) studied this question.

synapsesocial.com/papers/68c18c169b7b07f3a0615255 https://doi.org/10.1158/1541-7786.30050541

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Synapse has enriched 8 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary file 5: Table 5 from Mitochondrial HSP90 Paralog TRAP1 Deletion Drives Glutamine Addiction in Tumor Cells via Destablization of the Cys/Glu Antiporter SLC7A11/xCT2025
2Supplementary File 1: Table 1 from Mitochondrial HSP90 Paralog TRAP1 Deletion Drives Glutamine Addiction in Tumor Cells via Destablization of the Cys/Glu Antiporter SLC7A11/xCT2025
3Supplementary File 4: Table 4 from Mitochondrial HSP90 Paralog TRAP1 Deletion Drives Glutamine Addiction in Tumor Cells via Destablization of the Cys/Glu Antiporter SLC7A11/xCT2025
4Supplementary File 2: Table 2 from Mitochondrial HSP90 Paralog TRAP1 Deletion Drives Glutamine Addiction in Tumor Cells via Destablization of the Cys/Glu Antiporter SLC7A11/xCT2025
5Supplementary Figure S3 from Mitochondrial HSP90 Paralog TRAP1 Deletion Drives Glutamine Addiction in Tumor Cells via Destablization of the Cys/Glu Antiporter SLC7A11/xCT2025
6Supplementary File 3: Table 3 from Mitochondrial HSP90 Paralog TRAP1 Deletion Drives Glutamine Addiction in Tumor Cells via Destablization of the Cys/Glu Antiporter SLC7A11/xCT2025
7Supplementary Figure S5 from Mitochondrial HSP90 Paralog TRAP1 Deletion Drives Glutamine Addiction in Tumor Cells via Destablization of the Cys/Glu Antiporter SLC7A11/xCT2025
8Supplementary Figure S1 from Mitochondrial HSP90 Paralog TRAP1 Deletion Drives Glutamine Addiction in Tumor Cells via Destablization of the Cys/Glu Antiporter SLC7A11/xCT2025