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October 15, 2025

Figure S1 from SRSF9 Forms Phase-Separated Condensates to Promote Ovarian Cancer Progression by Inducing RNA Alternative Splicing That Is Inhibited by m⁶A Modification

Xinzhao Zuo Jie Xu Dan Yang Chenyue Yang Xiaoyi Liu Ningxuan Chen Haocheng Wang Xin Luo Qingya Luo Yuan Wang Qinglv Wei Yu Yang Hongyan Zhao Jing Xu Wei Wang Tao Liu Ping Yi

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Key Points

SRSF9 significantly enhances ovarian cancer progression through mechanisms linked to RNA splicing.
Key analysis involved public GEO datasets, including GSE10971 and GSE54388, with findings on SRSF9 expression.
Investigative methods focused on RNA levels of SR family members in relation to ovarian cancer status.
Results indicate that m6A modification may inhibit the cancer-promoting effects of SRSF9 on splicing.

Implication

Analysis reveals SRSF9 promotes RNA alternative splicing in ovarian cancer, suggesting m6A modification inhibits this process.

Abstract

Analysis of RNA levels of SR family members in ovarian cancer according to the public GEO datasets including GSE10971, GSE54388, and GSE27651.

Discussion

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Cite This Study

Zuo et al. (2025) studied this question.

synapsesocial.com/papers/68f199bfde32064e504dcac3 https://doi.org/10.1158/0008-5472.30363297

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S2 from SRSF9 Forms Phase-Separated Condensates to Promote Ovarian Cancer Progression by Inducing RNA Alternative Splicing That Is Inhibited by m<sup>6</sup>A Modification2025
2Figure S3 from SRSF9 Forms Phase-Separated Condensates to Promote Ovarian Cancer Progression by Inducing RNA Alternative Splicing That Is Inhibited by m<sup>6</sup>A Modification2025
3Figure S7 from SRSF9 Forms Phase-Separated Condensates to Promote Ovarian Cancer Progression by Inducing RNA Alternative Splicing That Is Inhibited by m<sup>6</sup>A Modification2025
4Figure S6 from SRSF9 Forms Phase-Separated Condensates to Promote Ovarian Cancer Progression by Inducing RNA Alternative Splicing That Is Inhibited by m<sup>6</sup>A Modification2025
5Table S2 from SRSF9 Forms Phase-Separated Condensates to Promote Ovarian Cancer Progression by Inducing RNA Alternative Splicing That Is Inhibited by m<sup>6</sup>A Modification2025