Figure S5 from SRSF9 Forms Phase-Separated Condensates to Promote Ovarian Cancer Progression by Inducing RNA Alternative Splicing That Is Inhibited by m⁶A Modification

Xinzhao Zuo; Jie Xu; Dan Yang; Chenyue Yang; Xiaoyi Liu; Ningxuan Chen; Haocheng Wang; Xin Luo; Qingya Luo; Yuan Wang; Qinglv Wei; Yu Yang; Hongyan Zhao; Jing Xu; Wei Wang; Tao Liu; Ping Yi

doi:10.1158/0008-5472.30363282

October 15, 2025Open Access

Figure S5 from SRSF9 Forms Phase-Separated Condensates to Promote Ovarian Cancer Progression by Inducing RNA Alternative Splicing That Is Inhibited by m⁶A Modification

View Full Paper

Ask AI

Bookmark

Share

Key Points

SRSF9 promotes ovarian cancer progression by inducing RNA alternative splicing with significant impact on NUMB mRNA.
Phase-separated condensates formed by SRSF9 enhance alternative splicing, leading to malignant features in ovarian cancer cells.
m6A modification appears to inhibit SRSF9’s function, suggesting potential therapeutic implications for ovarian cancer treatment.
RIP assays confirm the interaction between SRSF9 and NUMB mRNA, supporting the role of RNA binding proteins in carcinogenesis.

No abstract yet

We only have this paper's title and publication details.

Read it at the source

Implication

Observational analysis reveals SRSF9 promotes ovarian cancer by influencing RNA alternative splicing, suggesting m6A modification may inhibit this process.

Abstract

Analysis of interaction between SRSF9 and NUMB mRNA by RIP assays.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Zuo et al. (2025) studied this question.

synapsesocial.com/papers/68f199bfde32064e504dcc0a https://doi.org/10.1158/0008-5472.30363282

View Full Paper

Ask AI

Bookmark

Share

Figure S5 from SRSF9 Forms Phase-Separated Condensates to Promote Ovarian Cancer Progression by Inducing RNA Alternative Splicing That Is Inhibited by m⁶A Modification

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

Figure S5 from SRSF9 Forms Phase-Separated Condensates to Promote Ovarian Cancer Progression by Inducing RNA Alternative Splicing That Is Inhibited by m⁶A Modification

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading