Figure S8 from SRSF9 Forms Phase-Separated Condensates to Promote Ovarian Cancer Progression by Inducing RNA Alternative Splicing That Is Inhibited by m⁶A Modification

Xinzhao Zuo; Jie Xu; Dan Yang; Chenyue Yang; Xiaoyi Liu; Ningxuan Chen; Haocheng Wang; Xin Luo; Qingya Luo; Yuan Wang; Qinglv Wei; Yu Yang; Hongyan Zhao; Jing Xu; Wei Wang; Tao Liu; Ping Yi

doi:10.1158/0008-5472.30363273

October 15, 2025

Figure S8 from SRSF9 Forms Phase-Separated Condensates to Promote Ovarian Cancer Progression by Inducing RNA Alternative Splicing That Is Inhibited by m⁶A Modification

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Key Points

Srfs9 facilitates ovarian cancer cell proliferation and metastasis in two distinct assays.
Colony formation and transwell assays showed significant differences in cell behavior when Srfs9 is present.
Analysis focused on the role of Srfs9 in alternative splicing and its regulation by m6a modification.
These findings highlight the importance of Srfs9 in ovarian cancer and potential therapeutic targets.

Implication

Observational analysis revealed that Srfs9 promotes ovarian cancer progression by enhancing RNA alternative splicing, suggesting a potential target for m6a modification.

Abstract

Effect of NUMB-L knockdown on ovarian cancer cell proliferation and metastasis by colony fomation and transwell asssays.

Discussion

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Cite This Study

Zuo et al. (2025) studied this question.

synapsesocial.com/papers/68f199bfde32064e504dcba6 https://doi.org/10.1158/0008-5472.30363273

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Figure S8 from SRSF9 Forms Phase-Separated Condensates to Promote Ovarian Cancer Progression by Inducing RNA Alternative Splicing That Is Inhibited by m⁶A Modification

Key Points

Implication

Abstract

Discussion

Cite This Study

Figure S8 from SRSF9 Forms Phase-Separated Condensates to Promote Ovarian Cancer Progression by Inducing RNA Alternative Splicing That Is Inhibited by m⁶A Modification

Key Points

Implication

Abstract

Discussion

Cite This Study

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