Figure S6 from SRSF9 Forms Phase-Separated Condensates to Promote Ovarian Cancer Progression by Inducing RNA Alternative Splicing That Is Inhibited by m⁶A Modification

Q: What type of study is this?

This is a Experimental Study study.

Xinzhao Zuo; Jie Xu; Dan Yang; Chenyue Yang; Xiaoyi Liu; Ningxuan Chen; Haocheng Wang; Xin Luo; Qingya Luo; Yuan Wang; Qinglv Wei; Yu Yang; Hongyan Zhao; Jing Xu; Wei Wang; Tao Liu; Ping Yi

doi:10.1158/0008-5472.30363279

October 15, 2025Open Access

Figure S6 from SRSF9 Forms Phase-Separated Condensates to Promote Ovarian Cancer Progression by Inducing RNA Alternative Splicing That Is Inhibited by m⁶A Modification

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Key Points

SRSF9 promotes ovarian cancer progression by inducing RNA alternative splicing, which is inhibited by m6A modification.
The interaction between SRSF9 and NUMB mRNA is specifically blocked by m6A modification in ovarian cancer cells.
Researchers investigated how SRSF9 affects RNA splicing mechanisms, revealing a critical role in cancer cell behavior.
Findings highlight potential therapeutic strategies targeting m6A modification pathways in ovarian cancer management.

Implication

Experimental analysis shows SRSF9 forms condensates that enhance RNA splicing in ovarian cancer, suggesting m6A modification may inhibit this process.

Abstract

Interaction between SRSF9 and NUMB mRNA is inhibited by m6A modification in ovarian cancer cells.

Discussion

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Cite This Study

Zuo et al. (2025) studied this question.

synapsesocial.com/papers/68f199c5de32064e504dcdec https://doi.org/10.1158/0008-5472.30363279

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Figure S6 from SRSF9 Forms Phase-Separated Condensates to Promote Ovarian Cancer Progression by Inducing RNA Alternative Splicing That Is Inhibited by m⁶A Modification

Key Points

Implication

Abstract

Discussion

Cite This Study

Figure S6 from SRSF9 Forms Phase-Separated Condensates to Promote Ovarian Cancer Progression by Inducing RNA Alternative Splicing That Is Inhibited by m⁶A Modification

Key Points

Implication

Abstract

Discussion

Cite This Study

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