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October 15, 2025

Figure S10 from SRSF9 Forms Phase-Separated Condensates to Promote Ovarian Cancer Progression by Inducing RNA Alternative Splicing That Is Inhibited by m⁶A Modification

Xinzhao Zuo Jie Xu Dan Yang Chenyue Yang Xiaoyi Liu Ningxuan Chen Haocheng Wang Xin Luo Qingya Luo Yuan Wang Qinglv Wei Yu Xuan Yang Hongyan Zhao Jing Xu Wei Wang Tao Liu Ping Yi

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Key Points

SRSF9 promotes alternative splicing of NUMB mRNA, enhancing ovarian cancer progression and contributing to tumor development.
The presence of m6A modification inhibits SRSF9-mediated splicing, suggesting a regulatory mechanism in tumor biology.
Phase separation of SRSF9 forms condensates that play a crucial role in splicing regulation within the cancer cellular environment.
Targeted therapies may need to consider m6A modification's impact on RNA splicing to improve ovarian cancer treatment strategies.

Implication

Observational analysis uncovers SRSF9's role in RNA splicing in ovarian cancer, indicating m6A modification as a regulatory factor.

Abstract

Proposed model of SRSF9 condensation-mediated NUMB mRNA splicing that is inhibited by m6A modification in ovarian cancer.

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Cite This Study

Zuo et al. (2025) studied this question.

synapsesocial.com/papers/68f199bfde32064e504dcb2e https://doi.org/10.1158/0008-5472.30363294

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S6 from SRSF9 Forms Phase-Separated Condensates to Promote Ovarian Cancer Progression by Inducing RNA Alternative Splicing That Is Inhibited by m<sup>6</sup>A Modification2025
2Figure S5 from SRSF9 Forms Phase-Separated Condensates to Promote Ovarian Cancer Progression by Inducing RNA Alternative Splicing That Is Inhibited by m<sup>6</sup>A Modification2025
3Figure S9 from SRSF9 Forms Phase-Separated Condensates to Promote Ovarian Cancer Progression by Inducing RNA Alternative Splicing That Is Inhibited by m<sup>6</sup>A Modification2025
4Figure S8 from SRSF9 Forms Phase-Separated Condensates to Promote Ovarian Cancer Progression by Inducing RNA Alternative Splicing That Is Inhibited by m<sup>6</sup>A Modification2025
5Figure S3 from SRSF9 Forms Phase-Separated Condensates to Promote Ovarian Cancer Progression by Inducing RNA Alternative Splicing That Is Inhibited by m<sup>6</sup>A Modification2025