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October 15, 2025

Figure S9 from SRSF9 Forms Phase-Separated Condensates to Promote Ovarian Cancer Progression by Inducing RNA Alternative Splicing That Is Inhibited by m⁶A Modification

Xinzhao Zuo Jie Xu Dan Yang Chenyue Yang Xiaoyi Liu Ningxuan Chen Haocheng Wang Xin Luo Qingya Luo Yuan Wang Qinglv Wei Yu Xuan Yang Hongyan Zhao Jing Xu Wei Wang Tao Liu Ping Yi

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Key Points

SRSF9 promotes ovarian cancer progression by inducing RNA alternative splicing, enhancing cell proliferation.
In SRSF9-depleted cells, NUMB-L overexpression rescued effects on proliferation and metastasis, showing its significance.
Phase-separated condensates formed by SRSF9 are implicated in cancer development, highlighting new therapeutic targets.
M6A modification appears to inhibit the splicing effects of SRSF9, suggesting potential regulatory mechanisms to explore.

Implication

Analysis reveals SRSF9 promotes cell proliferation and metastasis in ovarian cancer, indicating m6A modification could inhibit these effects.

Abstract

Rescued effect of NUMB-L overexpression on the cell proliferation and metastasis in SRSF9-depleted ovarian cancer cells.

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Cite This Study

Zuo et al. (2025) studied this question.

synapsesocial.com/papers/68f199bfde32064e504dcb2d https://doi.org/10.1158/0008-5472.30363270

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S8 from SRSF9 Forms Phase-Separated Condensates to Promote Ovarian Cancer Progression by Inducing RNA Alternative Splicing That Is Inhibited by m<sup>6</sup>A Modification2025
2Figure S6 from SRSF9 Forms Phase-Separated Condensates to Promote Ovarian Cancer Progression by Inducing RNA Alternative Splicing That Is Inhibited by m<sup>6</sup>A Modification2025
3Figure S5 from SRSF9 Forms Phase-Separated Condensates to Promote Ovarian Cancer Progression by Inducing RNA Alternative Splicing That Is Inhibited by m<sup>6</sup>A Modification2025
4Figure S10 from SRSF9 Forms Phase-Separated Condensates to Promote Ovarian Cancer Progression by Inducing RNA Alternative Splicing That Is Inhibited by m<sup>6</sup>A Modification2025
5Figure S3 from SRSF9 Forms Phase-Separated Condensates to Promote Ovarian Cancer Progression by Inducing RNA Alternative Splicing That Is Inhibited by m<sup>6</sup>A Modification2025