Figure S2 from SRSF9 Forms Phase-Separated Condensates to Promote Ovarian Cancer Progression by Inducing RNA Alternative Splicing That Is Inhibited by m⁶A Modification

Xinzhao Zuo; Jie Xu; Dan Yang; Chenyue Yang; Xiaoyi Liu; Ningxuan Chen; Haocheng Wang; Xin Luo; Qingya Luo; Yuan Wang; Qinglv Wei; Yu Yang; Hongyan Zhao; Jing Xu; Wei Wang; Tao Liu; Ping Yi

doi:10.1158/0008-5472.30363291

October 15, 2025Open Access

Figure S2 from SRSF9 Forms Phase-Separated Condensates to Promote Ovarian Cancer Progression by Inducing RNA Alternative Splicing That Is Inhibited by m⁶A Modification

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Key Points

Ovarian cancer progression is linked to phase-separated condensates formed by SRSF9, and m6A modifies RNA splicing.
Correlation analysis reveals that higher expression of SR family members impacts overall and progression-free survival.
The research draws on data from the KM-plotter database to evaluate survival outcomes in ovarian cancer patients.
Understanding these mechanisms may highlight potential therapeutic targets for improving patient survival rates.

Implication

Analysis shows m6A modification inhibits RNA splicing in ovarian cancer, pointing to survival implications.

Abstract

Correlation analysis between SR family members’ expression and ovarian cancer patients’ overall survival and progression-free survival in patients by KM-plotter database.

Discussion

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Cite This Study

Zuo et al. (2025) studied this question.

synapsesocial.com/papers/68f199bfde32064e504dccc2 https://doi.org/10.1158/0008-5472.30363291

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Figure S2 from SRSF9 Forms Phase-Separated Condensates to Promote Ovarian Cancer Progression by Inducing RNA Alternative Splicing That Is Inhibited by m⁶A Modification

Key Points

Implication

Abstract

Discussion

Cite This Study

Figure S2 from SRSF9 Forms Phase-Separated Condensates to Promote Ovarian Cancer Progression by Inducing RNA Alternative Splicing That Is Inhibited by m⁶A Modification

Key Points

Implication

Abstract

Discussion

Cite This Study

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