What does this research mean for the field?

Nifedipine, but not enalapril, prevents the development of hypertension and glomerular injury in DOCA-salt rats, and this protective effect occurs independently of reductions in glomerular capillary pressure or inhibition of platelet aggregation. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

October 1, 1990AJP Renal Physiology

Effects of nifedipine and enalapril on glomerular injury in rats with deoxycorticosterone-salt hypertension

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Why the study?

Does nifedipine or enalapril prevent hypertension and glomerular injury in DOCA-salt hypertensive rats?

Population

Male Munich-Wistar rats that underwent right nephrectomy and were given weekly injections of…

Comparison

Enalapril or Nifedipine added to chow vs Controls (Study 1) or standard chow (Study 2)

Design

Preclinical

Follow-up

6 to 8 weeks after nephrectomy

Authors

LDLance D. DworkinUniversity of Toledo RLRichard I. LevinArnold P Gold Foundation JBJudith A. BensteinNew York University

Discussion

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Implication

Nifedipine effects in this rat model warrant no clinical translation; leaves open differential renoprotection by calcium channel blockade in salt-sensitive hypertension.

Structured PICO

Does nifedipine or enalapril prevent hypertension and glomerular injury in DOCA-salt hypertensive rats?

Population

Male Munich-Wistar rats that underwent right nephrectomy and were given weekly injections of deoxycorticosterone acetate (DOCA) and 1% saline (salt) to drink

Intervention

Enalapril (Study 1) or Nifedipine added to chow (Study 2)

Comparator

Controls (Study 1) or standard chow (Study 2)

Outcome

Development of hypertension and glomerular injury (proteinuria and glomerular lesions)surrogate

In a rat model of DOCA-salt hypertension, the calcium-channel blocker nifedipine, but not the ACE inhibitor enalapril, prevented the development of hypertension and glomerular injury.

Cite This Study

Dworkin et al. (1990) studied this question.

synapsesocial.com/papers/6a1925fec27e07dcc0d94df3 https://doi.org/10.1152/ajprenal.1990.259.4.f598

Topics

Hypertension management

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Implication

Nifedipine effects in this rat model warrant no clinical translation; leaves open differential renoprotection by calcium channel blockade in salt-sensitive hypertension.

Effects of nifedipine and enalapril on glomerular injury in rats with deoxycorticosterone-salt hypertension

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Effects of nifedipine and enalapril on glomerular injury in rats with deoxycorticosterone-salt hypertension

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

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