Key result
A PAI-1 activity rise greater than 3.7 U/mL during the first 24 hours of STEMI treatment with primary PCI was associated with significantly higher 5-year mortality (P<0.001).
Why the study?
Does PAI-1 activity rise > 3.7 U/mL predict death after 5 years in STEMI patients treated with primary PCI?
Cohort (n=87)
No
Does PAI-1 activity rise > 3.7 U/mL predict death after 5 years in STEMI patients treated with primary PCI?
p-value: p=<0.001
A rise in PAI-1 activity > 3.7 U/mL within the first 24 hours of STEMI is an independent predictor of 5-year mortality in patients treated with primary PCI.
No takes yet. Share an insight, caveat, or question.
May enhance post-PCI STEMI risk stratification; leaves open clinical utility pending larger prospective validation.
Pavlov et al. (2018) conducted a cohort in ST-elevation myocardial infarction (STEMI) (n=87). PAI-1 activity rise > 3.7 U/mL vs. PAI-1 activity rise ≤ 3.7 U/mL was evaluated on Death after 5 years (p=<0.001). A PAI-1 activity rise greater than 3.7 U/mL during the first 24 hours of STEMI treatment with primary PCI was associated with significantly higher 5-year mortality (P<0.001).
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