Why the study?
Does thromboxane inhibition improve contralateral kidney GFR and reduce systemic blood pressure in the 2K, 1C Goldblatt rat model of hypertension?
Population
Two-kidney, one-clip Goldblatt rat model of hypertension
Design
Preclinical
Follow-up
4 weeks
Authors
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Tx inhibition may restore contralateral GFR and lower BP in Goldblatt rats; hypothesis-generating for human renovascular hypertension.
Does thromboxane inhibition improve contralateral kidney GFR and reduce systemic blood pressure in the 2K, 1C Goldblatt rat model of hypertension?
In the 2K, 1C rat model of hypertension, increased renal thromboxane production impairs contralateral kidney function, and its inhibition restores function and lowers blood pressure.
Himmelstein et al. (1989) studied this question.
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