ESC Congress 2026 Hot Line Trials | Synapse

ESC Congress 2026 Hot Line Trials — European Society of Cardiology, Munich

58 Hot Line late-breaking trials presented across 12 sessions at ESC Congress 2026 in Munich, 28-31 August. Each trial includes PICO analysis, expert commentary, key results, and clinical implications.

CARDIO-TTRansform: Efficacy and safety of eplontersen in patients with transthyretin amyloid cardiomyopathy
Eplontersen did not meet the primary composite of cardiovascular death and recurrent cardiovascular events versus placebo through week 140.
— Cardiomyopathy
SINGLE-AF: Anticoagulation for atrial fibrillation with intermediate stroke risk — Atrial Fibrillation
POET-II: Tailored duration antibiotic treatment for infectious endocarditis
Simultaneous NEJM publication is live: response-tailored versus standard-duration antibiotic treatment for infective endocarditis.
— Endocarditis
ACACIA-HCM: Aficamten for the treatment of symptomatic nonobstructive hypertrophic cardiomyopathy
Aficamten met both primary endpoints versus placebo, improving KCCQ-CSS and peak VO2 at week 36 in symptomatic nonobstructive HCM.
— Cardiomyopathy
CMR GUIDE: Cardiac magnetic resonance GUIDEd management of mild-moderate left ventricular systolic dysfunction with an implantable cardioverter defibrillator — Devices & Arrhythmias
STAREE: Statins for Reducing Events in the Elderly — Prevention
AMUNDSEN: Evolocumab before percutaneous coronary intervention for acute myocardial infarction — Lipids
TRANQUILITY: Monthly and quarterly pacibekitug in patients with chronic kidney disease at high cardiovascular risk — Prevention
REACT: Prevalence of silent atherosclerosis across adult life — Prevention
ENRICH-AF: Edoxaban in intracranial haemorrhage survivors with atrial fibrillation — Atrial Fibrillation
DAN-RSV: RSVpreF vaccine for preventing cardiorespiratory hospitalisations — Prevention
LIBREXIA ACS: Milvexian after recent acute coronary syndrome — Acute Coronary Syndromes
PREMIUM: Aspirin omission at the time of primary percutaneous coronary intervention in ST-elevation myocardial infarction — Acute Coronary Syndromes
SWITCH SWEDEHEART: Switching from ticagrelor to prasugrel in acute coronary syndrome — Acute Coronary Syndromes
A-CLOSE: Clopidogrel monotherapy versus extended dual antiplatelet therapy after high-risk percutaneous coronary intervention — Interventional Cardiology
EPIDAURUS: Escalated single platelet inhibition for one month plus a non-vitamin K antagonist oral anticoagulant in patients with atrial fibrillation and acute coronary syndrome undergoing percutaneous coronary intervention — Interventional Cardiology
PRESC1SE-MI: Safety and efficacy of the ESC 0/1-hour algorithm for the rapid rule-out and rule-in of myocardial infarction — Acute Coronary Syndromes
0/1-hour versus standard care pathways in MI: 0/1-hour versus standard care diagnostic pathways in suspected myocardial infarction: a systematic review and individual patient data meta-analysis — Acute Coronary Syndromes
AIR-STEMI: Functional coronary angiography in ST-elevation myocardial infarction — Interventional Cardiology
TARGET-CTCA: Troponin in acute chest pain to risk stratify and guide computed tomography coronary angiography — Imaging
EMAIL-HF: Implementation of sodium-glucose co-transporter 2 inhibitors in heart failure through a digital strategy — Digital Health
Remote Exercise SWEDEHEART: Cardiac telerehabilitation: a cluster randomised cross-over trial — Digital Health
ADHERE-ASCVD: Adaptive digital outreach to improve statin adherence in atherosclerotic cardiovascular disease — Digital Health
VIRTUES ICD/PM: Digital platforms for patients with implantable cardioverter defibrillators and pacemakers — Digital Health
H-HeFT: Hydralazine-isosorbide dinitrate in patients with heart failure and reduced ejection fraction — Heart Failure
H-ISDN meta-analysis: Hydralazine-isosorbide dinitrate in heart failure with reduced ejection fraction: a meta-analysis — Heart Failure
Met-HeFT: Metformin in patients with chronic heart failure — Heart Failure
Met-HeFT meta-analysis: Metformin in heart failure and ischaemic heart disease: a meta-analysis — Heart Failure
LUMINARA: A once-daily oral relaxin agonist (AZD5462) in patients with heart failure — Heart Failure
PADN-PH-LHD: Pulmonary artery denervation for pulmonary hypertension due to left heart failure — Pulmonary Hypertension
TIME-HF: A team-based collaborative care model in heart failure — Heart Failure
POPular ACE TAVI: Routine versus selective protamine administration after transcatheter aortic valve implantation — Structural Heart
TAVI PCI: Percutaneous coronary intervention in patients undergoing transcatheter aortic valve implantation — Structural Heart
TRIC-I-HF: Tricuspid valve intervention in patients with heart failure — Structural Heart
ACASA-TAVI: Antithrombotic therapy after transcatheter aortic valve implantation — Structural Heart
NOTION-4: Subclinical leaflet thrombosis after transcatheter aortic valve implantation — Structural Heart
AFFIRMO: An integrated approach to atrial fibrillation in frail, multimorbid and polymedicated older people — Atrial Fibrillation
PVI-SHAM-AF: Pulmonary vein isolation versus sham procedure in patients with atrial fibrillation — Atrial Fibrillation
NEXAF: Long-term exercise training in patients with non-permanent atrial fibrillation — Atrial Fibrillation
IDEAL-AF: Individualised low-voltage area ablation in persistent atrial fibrillation — Atrial Fibrillation
SHASTA-3/4: Plozasiran in patients with severe hypertriglyceridaemia: 12-month results — Lipids
CRHCP: Long-term blood pressure control and the risk of dementia — Hypertension
BP-lowering treatment across the spectrum of CV risk: Blood pressure-lowering treatment across the spectrum of cardiovascular risk: an individual patient data meta-analysis — Hypertension
ECLIPSE-CKD: Salt substitution in patients with chronic kidney disease — Hypertension
ASPIRED: Immediate enhanced ambulatory electrocardiographic monitoring versus standard monitoring in acute unexplained syncope — Devices & Arrhythmias
DANISH-CRT: Targeted left ventricular lead placement for cardiac resynchronisation therapy in heart failure — Devices & Arrhythmias
SyncAV PMT: Clinical benefit of dynamic atrioventricular optimisation during cardiac resynchronisation therapy — Devices & Arrhythmias
Syncope-Stopper: Upfront pacing versus standard care in high-risk unexplained syncope — Devices & Arrhythmias
HIS Alternative II: His bundle pacing versus biventricular pacing in patients with heart failure — Devices & Arrhythmias
EVAOLD: Evaluation of reperfusion strategies in elderly patients — Interventional Cardiology
ISOLEDS: Intravascular ultrasound versus optical coherence tomography guidance for percutaneous coronary intervention of distal left main bifurcation lesions — Interventional Cardiology
CorCal: Pooled cohort equations versus coronary artery calcium score in primary prevention of atherosclerotic cardiovascular disease — Prevention
CoCAP: Graft patency in patients with acute coronary syndrome treated with dual antiplatelet therapy or aspirin alone after coronary artery bypass grafting — Cardiac Surgery
DISCO: Acute coronary angiography after resuscitated out-of-hospital cardiac arrest without ST-elevation on the electrocardiogram — Acute Cardiac Care
CAG after OHCA: Coronary angiography after out-of-hospital cardiac arrest without ST-elevation — Acute Cardiac Care
HeartRunner: Out-of-hospital cardiac arrest survival following community first responder activation — Acute Cardiac Care
Prague 26: Catheter-directed thrombolysis in intermediate-high-risk pulmonary embolism — Pulmonary Embolism
LAACS-2: Left atrial appendage closure concomitant with cardiac surgery — Cardiac Surgery